Water: Water Quality Standards Academy
Basic Course: Supplemental Topics - Health (n)
Toxicological Parameter for Cancer Effects (Linear): RSD
- Listing Impaired Waters and Developing TMDLs
- Monitoring & Assessment
- NPDES Permit Program
- Human Health Ambient Water Quality Criteria
- Historical Approach to Human Health Criteria Development
- Updated Approach
- Quantitative Risk Assessment
- Toxicological Parameter for Noncancer Effects
- Risk Assessment for Noncancer Effects
- Toxicological Parameter for Cancer Effects (Linear)
- Risk Assessment for Cancer Effects (Linear)
- Toxicological Parameter for Cancer Effects (Nonlinear)
- Risk Assessment for Cancer Effects (Nonlinear)
- Exposure Assessment
- Aquatic Life Criteria
The following equation is used for deriving linear cancer human health AWQC (mg/L). Note that the exposure and BAF terms in the equation have not changed except that this equation does not include an RSC.
EPA recommends using the RSD for a one-in-a-million extra risk (10-6 risk), but also accepts a one-in-a-hundred-thousand risk (10-5 risk) as long as the risk for highly exposed individuals does not exceed a one-in-ten-thousand (10-4) risk. The “extra” term in the definition of the RSD refers to a risk from environmental exposure to the chemical of interest above the background risk that is always present.
The RSD is derived by dividing the risk of interest (i.e., one-in-a-million) by the cancer slope factor (CSF or Q1* —note, however, that the Q1* abbreviation for the slope factor is gradually falling out of use):
Resource. The CSF (Q1*) values for individual chemicals can be located in their files in EPA’s IRIS database.